• Product NameA-366
• Brief DescriptionInhibitors
• Purification99.80%
• Biological ActivityPotent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50?= 3.3 nM). Exhibits >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. Decreases levels of lysine 9 dimethylation on histone H3 (H3K9Me2) in PC3 cells.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1527503-11-2
• Calculated MW 329.44
• Formulation C19H27N3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=C(C=C2C(=C1)C3(CCC3)C(=N2)N)OCCCN4CCCC4
  Pathways:Chromatin/Epigenetic
  Receptor:G9a/GLP
  Boling pt:
  Melting pt:
  Solubility:DMSO: 65 mg/mL (197.3 mM); Ethanol: 65 mg/mL (197.3 mM)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pappano WN, et al. PLoS One. 2015, 10(7):e0131716.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting