• Product NameIQ-1S
• Brief DescriptionInhibitors
• Purification97.92%
• Biological ActivityIQ-1S is a potent and selective c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S is highly specific for JNK and that its neutral form is the most abundant species at physiologic pH. IQ-1S can reduce inflammation and cartilage loss associated with CIA and can serve as a small-molecule modulator for mechanistic studies of JNK function in rheumatoid arthritis.
• Target NameJNK inhibitor
• CAS No. 23146-22-7
• Calculated MW 247.25
• Formulation C15H9N3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2
  Pathways:MAPK
  Receptor:JNK1; JNK2; JNK3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 32 mg/mL
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Igor A. Schepetkin et al. J Pharmacol Exp Ther, 2015 Jun, 353(3): 505-516.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting