• Product NamePF-8380
• Brief DescriptionInhibitors
• Purification99.25%
• Biological ActivityPotent autotaxin inhibitor (IC50?= 2.8 nM in isolated enzyme assay; 101 nM in human whole blood). Modulates lysophosphatidic acid (LPA) levels?in vivo?and?in vitro?by directly inhibiting autotaxin; reduces LPA levels both in plasma and at site of inflammation. Orally available.
• Target NamePDE inhibitor
• CAS No. 1144035-53-9
• Calculated MW 478.33
• Formulation C22H21Cl2N3O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1CN(CCN1CCC(=O)C2=CC3=C(C=C2)NC(=O)O3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl
  Pathways:Metabolism
  Receptor:Autotaxin
  Boling pt:
  Melting pt:
  Solubility:DMSO: 95 mg/mL (198.6 mM)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gierse J, et al. J Pharmacol Exp Ther. 2010, 334(1):310-317.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting