• Product NameSIS3
• Brief DescriptionInhibitors
• Purification95.64%
• Biological ActivitySelective Smad3 inhibitor; attenuates TGF-β1-dependent Smad3 phosphorylation and DNA binding. Has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. Inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts. Also inhibits TGF-β2-induced endothelial cell differentiation in iPSCs
• Target NameTGF-beta/Smad inhibitor
• CAS No. 521984-48-5
• Calculated MW 489.99
• Formulation C28H27N3O3HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN1C(=C(C2=C1N=CC=C2)/C=C/C(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl
  Pathways:Stem Cells
  Receptor:Smad3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 30 mg/mL
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Boudreau HE, et al. Br J Y. 2014 May 13;110(10):2569-82.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting