• Product NamePifithrin-β hydrobromide
• Brief DescriptionInhibitors
• Purification99.24%
• Biological ActivityInhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active?in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50?= 1.1?μM).?
• Target Namep53 inhibitor
• CAS No. 511296-88-1
• Calculated MW 349.29
• Formulation C16H17BrN2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br
  Pathways:Apoptosis
  Receptor:p53
  Boling pt:
  Melting pt:
  Solubility:DMSO: 26 mg/mL
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Abdelalim EM, et al.Biochem Biophys Res Commun. 2012 Apr 13;420(3):605-10.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting