• Product NameLeukadherin-1
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAllosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50?= 4?μM). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.
• Target NameIntegrin activator
• CAS No. 344897-95-6
• Calculated MW 421.49
• Formulation C22H15NO4S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1=CC=C(C=C1)CN2C(=O)/C(=C/C3=CC=C(O3)C4=CC=C(C=C4)C(=O)O)/SC2=S
  Pathways:Cytoskeletal Signaling
  Receptor:CD11b/CD18
  Boling pt:
  Melting pt:
  Solubility:DMSO: 6 mg/mL (Ultrasonic)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Reed JH, et al. J Biol Chem. 2013 Mar 29;288(13):9077-83.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting