• Product NameYL0919
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityYL0919, a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor,the IC50 values of YL-0919 inhibiting the uptake of 5-HT into rat cerebral cortical synaptosomes and human recombinant cells were 1.780.34 nM and 1.930.18 nM respectively.
• Target Name5-HT Receptor agonist
• CAS No. 1339058-04-6
• Calculated MW 334.84
• Formulation C18H23ClN2O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:Cl.O=C3C=CC=CN3CC2(O)CCN(Cc1ccccc1)CC2
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT; 5-HT1A
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chen HX, et al. PLoS One. 2013 Dec 18;8(12):e83271.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting