• Product NameAPY29
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAPY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
• Target NameOthers inhibitor
• CAS No. 1216665-49-4
• Calculated MW 332.36
• Formulation C17H16N8
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1CC1C2=CC(=NN2)NC3=NC(=NC=C3)NC4=CC5=C(C=C4)N=CN5
  Pathways:Others
  Receptor:IRE1α
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mg/mL
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wang L, et al. Nat Chem Biol. 2012 Dec;8(12):982-9.;

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting