• Product NameAZD3759
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityAZD3759 is a potent, oral active, central nervous system-penetrant, EGFR inhibitor. At Km ATP concentrations, the IC50 values were 0.3, 0.2, and 0.2 nM for EGFR TK wild-type, L858R mutant, and Exon 19Del enzymes, respectively.
• Target NameEGFR inhibitor
• CAS No. 1626387-80-1
• Calculated MW 459.9
• Formulation C22H23ClFN5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@@H]1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR (exon 19Del); EGFR (L858R); EGFR (WT)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 92 mg/mL (200.04 mM); Ethanol: 44 mg/mL warming (95.67 mM)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zeng Q, et al. J Med Chem. 2015, 58(20), 8200-8215.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting