• Product NameTHZ1
• Brief DescriptionInhibitors
• Purification99.27%
• Biological ActivityTHZ1 is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell's proliferation with IC50 of 50 nM.
• Target NameCDK inhibitor
• CAS No. 1604810-83-4
• Calculated MW 566.05
• Formulation C31H28ClN7O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK7
  Boling pt:
  Melting pt:
  Solubility:DMSO: 27 mg/mL
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kwiatkowski N, et al. Nature. 2014 Jul 31;511(7511):616-20.;Nilson KA, et al. Mol Cell. 2015 Aug 20;59(4):576-87.;

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting