- Product NameISO-1
- Brief DescriptionInhibitors
- Purification99.00%
- Biological ActivityMacrophage migration inhibitory factor (MIF) is a regulator of inflammation that also has roles in Y and autoimmune diseases.?MIF exhibits both tautomerase and oxidoreductase activities, although how these are linked to MIFs physiological and pathophysiological actions is unclear. MIF antagonist, also known as ISO-1, is an inhibitor of the dopachrome tautomerase activity of MIF?in vitro?(IC50?= 7 ?M) and in cells (IC50?= 25 ?M).?It blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and improves the survival of mice following sepsis.?MIF antagonist also demonstrates protective effects in airway and gastrointestinal inflammation in mice.
- Target NameOthers antagonist
- CAS No. 478336-92-4
- Calculated MW 235.2
- Formulation C12H13NO4
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
