• Product NameRuboxistaurin hydrochloride
• Brief DescriptionInhibitors
• Purification95.97%
• Biological ActivityIsozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50?values are 4.7 and 5.9 nM respectively). Selective for PKCβ?over other PKC isozymes (IC50values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100?μM for PKCη, -δ, -γ, -α, -ε?and -ζ?respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).
• Target NamePKC inhibitor
• CAS No. 169939-93-9
• Calculated MW 505.01
• Formulation C28H28N4O3HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolis
  SMILES:CN(C)C[C@@H]1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O.Cl
  Pathways:Cytoskeletal Signaling
  Receptor:PKCβ1; PKCβ2; PKCγ; PKCδ; PKCη
  Boling pt:
  Melting pt:
  Solubility:DMSO: 6.8 mg/mL (ultrasonic and warming)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Faul MM, et al. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1857-9.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting