- Product NameSAR131675
- Brief DescriptionInhibitors
- Purification99.10%
- Biological ActivitySAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively. SAR131675 was found to be highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is the first highly specific VEGFR-3-TK inhibitor described to date, displaying significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.
- Target NameVEGFR inhibitor
- CAS No. 1092539-44-0
- Calculated MW 358.16
- Formulation C18H22N4O4
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
