• Product NameGNE 477
• Brief DescriptionInhibitors
• Purification98.88%
• Biological ActivityGNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR.
• Target NamemTOR inhibitor; PI3K inhibitor
• CAS No. 1032754-81-6
• Calculated MW 504.63
• Formulation C21H28N8O3S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)S(=O)(=O)C
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:mTOR; PI3Kα
  Boling pt:
  Melting pt:
  Solubility:DMSO: 9.2 mg/mL
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Heffron TP, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2408-11.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting