• Product NameTebanicline
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTebanicline (ABT-594, Ebanicline), a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound. It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes.
• Target NameAChR agonist
• CAS No. 198283-73-7
• Calculated MW 198.65?
• Formulation C9H11ClN2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:C1CN[C@H]1COC2=CN=C(C=C2)Cl
  Pathways:Neuroscience
  Receptor:nAChR
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hayashi T, et al.Neurosci Lett. 2016 Dec 7;638:46-50.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting