• Product Namealpha-Asarone
• Brief DescriptionInhibitors
• Purification98.00%
• Biological Activityα-Asarone is a component of certain essential oils used in traditional Chinese herbal medicine. Although carcinogenic, α-asarone has been shown to be neuroprotective and radioprotective in mice when given at 50 mg/kg.?It also lowers serum cholesterol in rats, specifically reducing LDL-cholesterol levels and cholesterol saturation index, by directly inhibiting HMG-CoA reductase (IC50?= 3 mM).?α-Asarone also directly interacts with and inhibits certain isoforms of cytochrome P450 (IC50?= 55.2 and 65.2 μg/ml for CYP2D6 and CYP3A4, respectively).
• Target NameHMG-CoA Reductase inhibitor; P450 inhibitor
• CAS No. 2883-98-9
• Calculated MW 208.3
• Formulation C12H16O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism
  SMILES:C/C=C/C1=CC(=C(C=C1OC)OC)OC
  Pathways:Metabolism
  Receptor:HMGCR; CYP2D6; CYP3A4
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Limn, L, et al. Neuroscience Letters 453(2), 2009, 98-103.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting