• Product NameSCH900776 S-isomer
• Brief DescriptionInhibitors
• Purification99.95%
• Biological ActivitySCH900776 (S-isomer) is the S-isomer form of SCH900776(HY-15532), which is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent kinase CDK2 (IC50 = 160 nM).
• Target NameCDK inhibitor; Chk inhibitor
• CAS No. 891494-64-7
• Calculated MW 376.25
• Formulation C15H18BrN7
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C=C(C=N1)C2=C3N=C(C(=C(N3N=C2)N)Br)[C@H]4CCCNC4
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK2; Chk1; Chk2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 3 mg/mL (7.97 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Guzi TJ, et al. Mol Y Ther, 2011, 10(4), 591-602.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting