• Product NameABT-639
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityABT-639 is a potent and selective T-type calcium channel blocker. ABT-639 effectively reduces nociceptive and neuropathic pain in rats. ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat. ABT-639 was significantly less active at other Ca?? channels (e.g. Ca(v)1.2 and Ca(v)2.2) (IC?? > 30 μM). ABT-639 has high oral bioavailability (%F = 73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents.
• Target NameCalcium Channel inhibitor
• CAS No. 1235560-28-7
• Calculated MW 455.08
• Formulation C19H18F3N3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism
  SMILES:C1C[C@@H]2CN(CCN2C1)C(=O)C3=CC(=C(C=C3Cl)F)S(=O)(=O)NC4=CC=CC=C4F
  Pathways:Membrane transporter/Ion channel
  Receptor:Calcium Channel
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Jarvis MF, et al. Biochem Pharmacol. 2014 Jun 15;89(4):536-44.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting