• Product NameGNE-3511
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityGNE-3511 is a potent and selective dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. GNE-3511 displays concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. GNE-3511 displays protection of primary neurons in an in vitro axon degeneration assay as well as activity in the mouse models of glaucoma/optic neuropathy (optic nerve crush) and Parkinsons disease (MPTP) after oral dosing.
• Target NameDNA Alkylation inhibitor; MAPK inhibitor
• CAS No. 1496581-76-0
• Calculated MW 440.21
• Formulation C23H26F2N6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:N#CC1=CC(NC2=NC(N3CC(F)(F)CC3)=CC(C4CCN(C5COC5)CC4)=C2)=NC=C1
  Pathways:DNA Damage/DNA Repair; MAPK
  Receptor:DLK; MAP3K12
  Boling pt:
  Melting pt:
  Solubility:DMSO: 32 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Patel S, et al. J Med Chem. 2015 Jan 8;58(1):401-18.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting