- Product NameBP-1-102
- Brief DescriptionInhibitors
- Purification99.00%
- Biological ActivityBP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor. BP-1-102 binds Stat3 with an affinity (K(D)) of 504 nM, blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 μM, and selectively inhibits growth, survival, migration, and invasion of Stat3-dependent tumor cells. BP-1-102-mediated inhibition of aberrantly active Stat3 in tumor cells suppresses the expression of c-Myc, Cyclin D1, Bcl-xL, Survivin, VEGF, and Kr??ppel-like factor 8, which is identified as a Stat3 target gene that promotes Stat3-mediated breast tumor cell migration and invasion.
- Target NameSTAT inhibitor
- CAS No. 1334493-07-0
- Calculated MW 626.15
- Formulation C29H27F5N2O6S
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
