• Product NameRAF709
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityRAF709 is a novel?Raf?kinase inhibitor extracted from patent WO2014151616A1, compound example 131, has an?IC50?of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.
• Target NameRaf inhibitor
• CAS No. 1628838-42-5
• Calculated MW 542.21
• Formulation C28H29F3N4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:O=C(NC1=CN=C(C)C(C2=CC(N3CCOCC3)=C(OC4CCOCC4)N=C2)=C1)C5=CC(C(F)(F)F)=CC=C5
  Pathways:MAPK
  Receptor:B-Raf; C-Raf
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Robert AVERSA, et al. WO2014151616A1.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting