• Product NameEthyl gallate
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityEthyl gallate obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhibit the abilities of invasion of breast cancer in vitro by inhibiting the mRNA levels of MMP-9/MMP-2, phosphorylation of Akt and protein expression of NF-κB and inhibits hydrogen peroxide signaling, may represent an alternative class of vasopressors for use in septic shock. Also, Ethyl gallate suppresses proliferation and invasion in human breast cancer cells by modulating the PI3K/Akt pathway, which may contribute to inhibiting their downstream targets such as NF-κB p-65, Bcl-2/Bax, and mRNA levels of MMP-2 and MMP-9 in breast cancer cells, could be used as potential antioxidants with safe therapeutic application in cancer chemotherapy.
• Target NameAkt inhibitor; MMP inhibitor; NF-κB inhibitor
• CAS No. 831-61-8
• Calculated MW 198.17
• Formulation C9H10O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CCOC(=O)C1=CC(=C(C(=C1)O)O)O
  Pathways:Cytoskeletal Signaling; NF-κb; Proteases/Proteasome; PI3K/Akt/mTOR signaling
  Receptor:Akt; MMP-2; MMP-9; NF-κB
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Cui H, et al. Oncol Rep. Ethyl gallate suppresses proliferation and invasion in human breast cancer cells via Akt-NF-κB signaling. 2015 Mar;33(3):1284-90.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting