• Product NameRhapontigenin
• Brief DescriptionInhibitors
• Purification99.88%
• Biological ActivityRhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50?= 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens.1?At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50?= 48 μM).
• Target NameP450 inhibitor
• CAS No. 500-65-2
• Calculated MW 258.3
• Formulation C15H14O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology/Cardiovascular system/Cancer/
  SMILES:COC1=C(C=C(C=C1)/C=C/C2=CC(=CC(=C2)O)O)O
  Pathways:Metabolism
  Receptor:CYP1A1
  Boling pt:
  Melting pt:
  Solubility:Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Jo SP1, Kim JK2, Lim YH1.Antihyperlipidemic effects of rhapontin and rhapontigenin from rheum undulatum in rats fed a high-cholesterol diet.Planta Med. 2014 Aug;80(13):1067-71.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting