• Product NamePraeruptorinA
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPraeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis.
• Target NameCaMK inhibitor
• CAS No. 73069-27-9
• Calculated MW 386.4
• Formulation C21H22O7
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology/Cardiovascular system/
  SMILES:C/C=C(/C)\C(=O)O[C@H]1[C@H](C2=C(C=CC3=C2OC(=O)C=C3)OC1(C)C)OC(=O)C
  Pathways:Neuroscience
  Receptor:CAM
  Boling pt:
  Melting pt:
  Solubility:Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Xu Z1, Wang X, Dai Y, Kong L, et al.(+/-)-Praeruptorin A enantiomers exert distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis.Chem Biol Interact. 2010 Jul 30;186(2):239-46.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting