• Product NameVelutin
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityVelutin has anti-inflammatory property. Velutin exhibits the greatest potency among all flavones in reducing TNF-α and IL-6 production. Velutin shows the strongest inhibitory effect in nuclear factor (NF)-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK phosphorylation.
• Target NameNF-κB inhibitor
• CAS No. 25739-41-7
• Calculated MW 314.293
• Formulation C17H14O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:COC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC(=C(C=C3)O)OC)O
  Pathways:NF-κb
  Receptor:NF-κB
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Xie C, et al. The a?a flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway. J Nutr Biochem. 2012 Sep;23(9):1184-91.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting