• Product NameChikusetsusaponin IVa
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityChikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into a new potential for therapeutic agent used in T2DM patients.
• Target NameAMPK activator
• CAS No. 51415-02-2
• Calculated MW 794.976
• Formulation C42H66O14
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism/Immunology/
  SMILES:C[C@]12CC[C@@H](C([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)(C)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:AMPK
  Boling pt:
  Melting pt:
  Solubility:Pyridine, Methanol, Ethanol
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Li Y, ET AL. Chikusetsu saponin IVa regulates glucose uptake and fatty acid oxidation: implications in antihyperglycemic and hypolipidemic effects. J Pharm Pharmacol. 2015 Jul;67(7):997-1007.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting