• Product NameGK921
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGK921 is a transglutaminase 2 (TGase 2) inhibitor with average GI50 of 0.9 uM in cancer cell lines.
• Target NameGlutaminase inhibitor
• CAS No. 1025015-40-0
• Calculated MW 344.418
• Formulation C21H20N4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1CCN(C1)CCOC2=C(N=C3C(=N2)C=CC=N3)C#CC4=CC=CC=C4
  Pathways:Proteases/Proteasome
  Receptor:TGase
  Boling pt:
  Melting pt:
  Solubility:DMSO: 30 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ku BM,et al. Transglutaminase 2 inhibitor abrogates renal cell carcinoma in xenograft models.J Cancer Res Clin Oncol. 2014 May;140(5):757-67.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting