• Product NameAZD9496
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAZD9496 is an oral estrogen receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models.
• Target NameEstrogen/progestogen Receptor inhibitor
• CAS No. 1639042-08-2
• Calculated MW 442.47
• Formulation C25H25F3N2O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C[C@@H]1CC2=C([C@H](N1CC(C)(C)F)C3=C(C=C(C=C3F)/C=C/C(=O)O)F)NC4=CC=CC=C24
  Pathways:Endocrinology/Hormones
  Receptor:ERα; ERα; ERα
  Boling pt:
  Melting pt:
  Solubility:DMSO: 88 mg/mL (198.88 mM); Ethanol : 88 mg/mL (198.88 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Weir HM et al. AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models. Cancer Res. 2016 Jun 1;76(11):3307-18.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting