• Product NameCytosporone B
• Brief DescriptionInhibitors
• Purification98.00%
• Biological Activityytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).1 Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself.1 Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth.1 It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet.1,2 Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage.3 Cytosporone B also has antibacterial properties.4
• Target NameOthers agonist
• CAS No. 321661-62-5
• Calculated MW 322.401
• Formulation C18H26O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CCCCCCCC(=O)C1=C(C=C(C=C1CC(=O)OCC)O)O
  Pathways:Others
  Receptor:Nur77
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhan, Y. , et al. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chemical Biology 4, 548-556 (2008).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting