• Product NameTMP 195
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySelective and cell-active class IIa histone deacetylase (HDAC) inhibitor, with IC50 values of 111, 106, 46, 9 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively; >100 fold more selective vs other HDACs (IC50: >10 μM).The trifluoromethyloxadiazole (TFMO) moiety in TMP 195 as a new metal binding group circumvents the selectivity and pharmacologic liabilities of hydroxamates groups used in other metalloenzyme inhibitors. TMP 195 has a restraint impact on gene expression, and lacks overt cytotoxicity.
• Target NameHDAC inhibitor
• CAS No. 1314891-22-9
• Calculated MW 456.425
• Formulation C23H19F3N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(C)(CNC(=O)C1=CC=CC(=C1)C2=NOC(=N2)C(F)(F)F)C3=COC(=N3)C4=CC=CC=C4
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κb
  Receptor:HDAC4; HDAC5; HDAC7; HDAC9
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lobera M., et al. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting