• Product NameSF2523
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySF2523 is a highly selective and potent inhibitor of PI3K and BRD4with IC50 values of 16 and 241 nM for PI3Kα and BD1, respectively.
• Target NameDNA-PK inhibitor; Epigenetic Reader Domain inhibitor; mTOR inhibitor; PI3K inhibitor
• CAS No. 1174428-47-7
• Calculated MW 371.41
• Formulation C19H17NO5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:O=C1C=C(N2CCOCC2)OC3=C1SC=C3C4=CC=C(OCCO5)C5=C4
  Pathways:DNA Damage/DNA Repair; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
  Receptor:DNA-PK; BRD4; mTOR; PI3Kα; PI3Kγ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 30 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Andrews FH., et al. Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1072-E1080.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting