• Product NameE 6005; RVT-501
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityE6005 is a phosphodiesterase 4 (PDE-4) inhibitor potentially for the treatment of atopic dermatitis.
• Target NamePDE inhibitor
• CAS No. 947620-48-6
• Calculated MW 472.17
• Formulation C26H24N4O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:O=C(OC)C1=CC=C(C(NC2=CC=CC(C3=C4C=C(OC)C(OC)=CC4=NC(NC)=N3)=C2)=O)C=C1
  Pathways:Metabolism
  Receptor:PDE4
  Boling pt:
  Melting pt:
  Solubility:DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nemoto O., et al. Effect of topical phosphodiesterase 4 inhibitor E6005 on Japanese children with atopic dermatitis: Results from a randomized, vehicle-controlled exploratory trial. J Dermatol. 2016 Aug;43(8):881-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting