- Product NamePIM1/2 Kinase Inhibitor VI
- Brief DescriptionInhibitors
- Purification98.00%
- Biological ActivityA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 ?M), while exhibiting little or no activity against a panel of 57 other kinases (18% inhibition at 5 ?M). Reported to exhibit antitumor activity both in PC3 human prostate cancer cultures in vitro (IC50 = 48 ?M) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20; 50 mg/kg via daily i.p.).
- Target NamePim inhibitor
- CAS No. 587852-28-6
- Calculated MW 263.311
- Formulation C13H13NO3S
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
