• Product Name()-Equol
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityEquol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora.?The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50?= 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein.?(S)-Equol preferentially binds ERβ (Ki?= 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki?= 6.41 nM).?(S)-equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.
• Target NameEstrogen/progestogen Receptor agonist
• CAS No. 94105-90-5
• Calculated MW 242.3
• Formulation C15H14O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:OC1=CC=C2CC(C3=CC=C(O)C=C3)COC2=C1
  Pathways:Endocrinology/Hormones
  Receptor:ERα; ERβ
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Mahalingam S, Gao L, Gonnering M, Helferich W, et al.Toxicol Appl Pharmacol. 2016 Mar 15;295:47-55.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting