• Product NameNCB-0846
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityNCB-0846 is an orally available TNIK inhibitor with an IC50 of 21?nM.
• Target NameWnt/beta-catenin inhibitor
• CAS No. 1792999-26-8
• Calculated MW 375.42
• Formulation C21H21N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1CC(CCC1O)OC2=CC=CC3=CN=C(N=C32)NC4=CC5=C(C=C4)N=CN5
  Pathways:Cytoskeletal Signaling; Stem Cells
  Receptor:TNIK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 30 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Masuda M, et al. TNIK inhibition abrogates colorectal cancer stemness. Nat Commun. 2016 Aug 26;7:12586.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting