• Product NameUNC 926 hydrochloride
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityUNC-926 inhibits L3MBTL1 with an IC50 of 3.9 μM. UNC-926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3, with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively inhibits the L3MBTL13xMBT-H4K20me1 interaction in a dose-dependent manner. UNC-926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC-926 for L3MBTL1 over 53BP1.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 1184136-10-4
• Calculated MW 373.72
• Formulation C16H21BrN2O.HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=CC=C3)Br
  Pathways:Chromatin/Epigenetic
  Receptor:L3MBTL1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mM; Water: 100 mM
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Herold JM, et al. StructureCactivity relationships of methyl-lysine reader antagonists. MedChemComm. 2012;3(45):45C51.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting