• Product NameHG-14-10-04
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityHG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM. IC50 value: 20 nM Target: ALK More information can be found in the following Patent, Example 10 Preparation of substituted pyrimidinamines as ALK kinase inhibitors By Aquila, Brian; Kamhi, Victor; Peng, Bo; Pontz, Timothy; Saeh, Jamal Carlos; Thakur, Kumar; Yang, Bin From U.S. Pat. Appl. Publ. (2012), US 20120028924 A1 20120202.
• Target NameALK inhibitor
• CAS No. 1356962-34-9
• Calculated MW 532.08
• Formulation C29H34ClN7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN1CCN(C2CCN(C3=CC=C(NC4=NC=C(Cl)C(C5=CNC6=C5C=CC=C6)=N4)C(OC)=C3)CC2)CC1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 13.3 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.U.S. Pat. Appl. Publ. (2012), US 20120028924 A1

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting