• Product NameCambinol
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1 and SIRT2 (IC50 = 56 μM and 59 μM, respectively) in a substrate-, but not NAD-, competitive manner. SIRT1/2 Inhibitor IV, Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and exhibits no inhibition against class I and II HDACs. Cambinol-induced apoptosis in BCL6-expressing Burkitt lymphoma cell lines has been attributed to the hyperacetylation of BCL6 and p53.
• Target NameSirtuin inhibitor
• CAS No. 14513-15-6
• Calculated MW 360.09
• Formulation C21H16N2O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:O=C(C(CC1=C2C=CC=CC2=CC=C1O)=C(C3=CC=CC=C3)N4)NC4=S
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:SIRT1; SIRT2
  Boling pt:
  Melting pt:
  Solubility:DMSO:10 mg/ml; ethanol (5 mg/ml
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lugrin J.,et al. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta. 2013 Jun;1833(6):1498-510.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting