• Product NameUNC3866
• Brief DescriptionInhibitors
• Purification95.00%
• Biological ActivityUNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen (IC50=661.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel.
• Target NameHistone Methyltransferase antagonist
• CAS No. 1872382-47-2
• Calculated MW 795.02
• Formulation C43H66N6O8
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(C)(C)C1=CC=C(C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN(CC)CC)C(N[C@@H](CO)C(OC)=O)=O)=O)=O)=O)=O)C=C1
  Pathways:Chromatin/Epigenetic
  Receptor:CBX7-H3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 27 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Stuckey JI, et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat Chem Biol. 2016 Mar;12(3):180-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting