• Product NameQS 11
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityQS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.
• Target NameGTPase inhibitor
• CAS No. 944328-88-5
• Calculated MW 567.7
• Formulation C36H33N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:OC[C@H](CC1=CC=CC=C1)NC2=C3C(N(CC4=CC=C(C5=CC=CC=C5)C=C4)C=N3)=NC(OC6=CC=C(CCC7)C7=C6)=N2
  Pathways:GPCR/G Protein
  Receptor:ARFGAP1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mM; ethanol: 100 mM
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Emre N., et al. A chemical approach to stem cell biology. Curr Opin Chem Biol. 2007 Jun;11(3):252-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting