• Product NameVEGFR2 KiN/Ase Inhibitor I
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityVascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kiN/Ase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kiN/Ase inhibitor I is a potent, cell-permeable inhibitor of mouse VEGFR2 kiN/Ase (IC50 = 70 nM).1 It has little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50 > 100 ?M).
• Target NameVEGFR inhibitor
• CAS No. 15966-93-5
• Calculated MW 310.35
• Formulation C18H18N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CCOC(=O)C1=C(NC(=C1C)C=C2C3=CC=CC=C3NC2=O)C
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:VEGFR2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mg/ml
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sun L, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kiN/Ase inhibitors that exhibit selectivity toward particular receptor tyrosine kiN/Ases. J Med Chem. 1998 Jul 2;41(14):2588-603.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting