- Product NameBTB-1
- Brief DescriptionInhibitors
- Purification98.00%
- Biological ActivityBTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A, which was identified by Catarinella et al. during a highthroughput screen against Kif18A?s MT-stimulated ATPase activity, with an IC50 of 1.7?C1.9 M . It is selective within the kinesin subgroup of Kif4, Eg5, MKLP-1, MKLP-2, MPP1, CENP-E and MCAK, and during in vitro motility assays Kif18A?s MT gliding ability was blocked by the addition of BTB-1 in a reversible manner. BTB-1 was found to be ATP competitive and MT uncompetitive, only inhibiting the ATPase activity of the MT-bound motor protein. BTB-1 could serve as a valuable tool in disentangling the N/Ature of Kif18A?s double functioN/Ality within mitosis and assessing for potential therapeutic utilities.
- Target NameMicrotubule Associated inhibitor
- CAS No. 86030-08-2
- Calculated MW 297.71
- Formulation C12H8ClNO4S
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
