• Product NameSolamargine
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySolamargine is a major steroidal alkaloid glycoside extracted from a traditioN/Al Chinese mediciN/Al herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.
• Target Namep38 MAPK inhibitor; STAT inhibitor
• CAS No. 20311-51-7
• Calculated MW 868.07
• Formulation C45H73NO15
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)C)C)C)NC1
  Pathways:JAK/STAT signaling; MAPK; Stem Cells
  Receptor:p38 MAPK; STAT3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 8.8 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sani IK., et al. Solamargine inhibits migration and invasion of human hepatocellular carcinoma cells through down-regulation of matrix metalloproteiN/Ases 2 and 9 expression and activity. Toxicol In Vitro. 2015 Aug;29(5):893-900.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting