• Product NameETC-159
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
• Target NameWnt/beta-catenin inhibitor
• CAS No. 1638250-96-0
• Calculated MW 391.38
• Formulation C19H17N7O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4
  Pathways:Cytoskeletal Signaling; Stem Cells
  Receptor:β-catenin
  Boling pt:
  Melting pt:
  Solubility:DMSO: 34 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Madan B, et al. Wnt addiction of genetically defined cancers reversed by PORCN inhibition. Oncogene. 2015 Aug 10. doi: 10.1038/onc.2015.280.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting