• Product NameBX-517
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityBX-517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.
• Target NamePDK inhibitor
• CAS No. 850717-64-5
• Calculated MW 282.3
• Formulation C15H14N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C/C(=C/1\C2=C(C=CC(=C2)NC(=O)N)NC1=O)/C3=CC=CN3
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PDK1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 27 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3819-25.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting