• Product NameBisantrene
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityBisantrene is a highly effective antitumor drug, targets eukaryotic type II topoisomerases.
• Target NameTopoisomerase
• CAS No. 78186-34-2
• Calculated MW 398.46
• Formulation C22H22N8
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1NC(=NC1)N/N=C/C2=C3C(=C(C4=CC=CC=C24)/C=N/NC5=NCCN5)C=CC=C3
  Pathways:DNA Damage/DNA Repair
  Receptor:Topoisomerase
  Boling pt:
  Melting pt:
  Solubility:DMSO: 133.33 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54(6):1036-45.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting