• Product NameAST 487
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.
• Target Namec-Kit inhibitor; c-RET inhibitor; FLT inhibitor; VEGFR inhibitor
• CAS No. 630124-46-8
• Calculated MW 529.56
• Formulation C26H30F3N7O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=NC=NC(=C4)NC)C(F)(F)F
  Pathways:Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
  Receptor:c-Kit; RET; FLT4; KDR
  Boling pt:
  Melting pt:
  Solubility:10 mM in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Akeno-Stuart N, et al. The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells. Cancer Res. 2007 Jul 15;67(14):6956-64.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting