• Product NameAcelarin
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAcelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine.
• Target NameDNA/RNA Synthesis inhibitor
• CAS No. 840506-29-8
• Calculated MW 580.47
• Formulation C25H27F2N4O8P
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@H](NP(OC1=CC=CC=C1)(OC[C@H]2O[C@@H](N3C=CC(N)=NC3=O)C(F)(F)[C@H]2O)=O)C(OCC4=CC=CC=C4)=O
  Pathways:DNA Damage/DNA Repair
  Receptor:DNA synthesis
  Boling pt:
  Melting pt:
  Solubility:DMSO: 36 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Slusarczyk M, et al. Application of ProTide technology to gemcitabine: a successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical development. J Med Chem. 2014 Feb 27;57(4):1531-42.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting