• Product NameTPX-0005
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.
• Target NameALK inhibitor; Src inhibitor
• CAS No. 1802220-02-5
• Calculated MW 355.37
• Formulation C18H18FN5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:Fc1cc2c(cc1)O[C@@H](C)CNC(=O)c4cnn3ccc(N[C@@H]2C)nc34
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK; Src
  Boling pt:
  Melting pt:
  Solubility:DMSO: 83.3 mg/Ml
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Dayong Zhai, et al. Abstract 2132: The novel, rationally-designed, ALK/SRC inhibitor TPX-0005 overcomes multiple acquired resistance mechanisms to current ALK inhibitors. Cancer Research. July 2016

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting