• Product NameGSK872
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGSK'872 (GSK2399872A) is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity.
• Target NameTNF inhibitor
• CAS No. 1346546-69-7
• Calculated MW 383.48
• Formulation C19H17N3O2S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=CC4=C(C=C3)SC=N4
  Pathways:Apoptosis
  Receptor:RIP3K
  Boling pt:
  Melting pt:
  Solubility:DMSO: 76 mg/mL (198.17 mM); Ethanol: 40 mg/mL (104.3 mM); Water: Insoluble
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1 Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014, 56(4):481-95.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting